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UC Davis Data Coordinating Center

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The American Burn Association Data Coordinating Center at UC Davis (DCC)

is responsible for assisting MCTG investigators in all aspects of study implementation and conduct, data management and analysis, biostatistical expertise, adverse event reporting and assistance with publication of research findings. The DCC works with the study PI and staff, the MCTG Steering Committee, Medical Monitors and DSMB throughout all phases of the research project.

Functional Areas of the DCC:

  • Clinical Core
  • Informatics Core
  • BioStatistics Core

 

Active Projects

 

 

A Randomized Clinical Trial of Restrictive vs. Traditional Blood Transfusion Practices in Burn Patients (Transfusion Trigger)

 

To compare the outcome of a restrictive blood transfusion policy (maintaining a hemoglobin level 7-8g/dL) vs. a traditional transfusion policy (maintaining hemoglobin 10-11 g/dL) on the incidence of blood stream infection, hospital length of stay, duration of mechanical ventilation, mortality, and wound healing after major burn injury in adults.

 

 

The Relationship of Rehabilitation Therapy Time to The Prevention of Burn Scar Contracture (ACT) 

 

The aim of the project will be the generation and establishment of a burn rehabilitation database through the prospective collection of information pertinent to rehabilitation patient outcomes, namely the prevention of burn scar contracture.  Information collected will primarily focus on the association between burn patient acuity, scar contracture development and the amount of time patients receive rehabilitation treatments.

 

 

Rapid Detection of Staphylococcus Aureus in Burn Patients (PCR-Staph)

 

This is a multicenter (UC Davis Medical Center, University of Washington Harborview Medical Center, University of Cincinnati Medical Center, and University of Miami Ryder Trauma Center), randomized control trial evaluating the clinical benefit of rapid polymerase chain reaction (PCR)-based detection of Staphylococcus aureus and MRSA in burn sepsis patients.  In parallel, the study evaluates the clinical utility of quantitative PCR in determining the severity and treatment efficacy of S. aureus- or MRSA-related burn sepsis.  The study is sponsored by the American Burn Association and funded by the United States Army Medical Research and Material Command.

 

 

Effects of a Community Based Exercise Program in Adults with Severe Burns (COMBEX)

 

The purpose of this study is to assess the efficacy of implementing a 12-week structured and supervised community-based exercise program (COMBEX) at hospital discharge.  This study will assess the effect of exercise on mental health and physical function, along with its effects on the amelioration of the burn-induced catabolic response.

 

 

Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure (RESCUE)

 

This is a multicenter non-blinded randomized controlled trial comparing intervention with early high-volume hemofiltration (HVHF) plus 'contemporary' care versus 'contemporary' care alone in the treatment of critically ill patients with ARF secondary to septic shock.

 

 

Inhalation Severity of Injury Score (ISIS)

 

The goal of this multicenter study is to develop a standardized scoring system for inhalation injury that can be used both to quantify and predict injury severity inhalation injury in adults over 18 years of age. Our hypothesis is that we can develop a model based on clinical, radiographic, bronchoscopic, and biochemical parameters that will predict the severity of inhalation injury with greater than 80% predictive accuracy. More information 

 

 

Sentinel Gene Expression to Forecast Outcomes and Monitor Treatment Protocols in Combined Burn/Trauma

 

The overall objectives of this Demonstration Research Project are to establish whether changes in a newly recognized representative of 'sentinel' genes expressed in normal tissues can forecast the severity of responses to injury, the clinical outcomes after injury and the specific therapeutic strategies that should be deployed in patients with burn, trauma and burn/trauma.

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There are currently no upcoming events.

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